Actinobacteria have become major players in the field of biological control, which is an eco-friendly method of controlling plant diseases. A vast range of secondary metabolites with antibacterial properties are produced by these gram-positive bacteria, which are well known for their varied metabolic capabilities. Actinobacteria can successfully inhibit the growth of harmful plant pathogens through a variety of methods, including competition for resources, antibiotic synthesis, and stimulation of plant defensive responses. In addition to advancing our understanding of microbial ecology, an understanding of these interactions leads the way for the development of sustainable farming methods that reduce the need for chemical pesticides, therefore encouraging healthier ecosystems and increasing crop yields. This innovative approach highlights the value of actinobacteria and their function in managing plant diseases. It also shows how these natural processes can be used in biocontrol strategies, opening the door to sustainable solutions that have the potential to modify agricultural practices around the world. In addition to improving our understanding of actinobacteria's function in soil health, knowing the precise mechanisms of action they use helps design focused biocontrol strategies that can effectively target plant pathogens while reducing the need for chemical solutions. Sustainable farming methods that put ecological balance first and encourage long-term soil fertility are what this strategy aims to promote. Here, we provide an overview of using actinobacteria as a biological control against various plant pathogens and its important secondary metabolites.