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411864

Acetylcholine Esterase Inhibition in Alzheimer's Therapy: Spotlight on Quinzolinone Derivatives

Article

Last updated: 25 Feb 2025

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Subjects

-

Tags

Pharmaceutical Sciences

Abstract

As the most prevalent type of dementia with a high rate of mortality and disability, Alzheimer's disease (AD) poses serious and growing global issues. Its etiology is complex, serious and multifaceted, resulting from a confluence of environmental, genetic, and age variables. The cholinergic, amyloid, tau protein, oxidative stress, and inflammatory hypotheses are some of the theories that now underlie our understanding of AD pathology. However, more clarification and verification are needed to identify the main reasons causing AD and to understand how these clinical features interact. The cholinergic hypothesis states that Alzheimer's disease impairs the brain's cholinergic function, which results in decreased levels of the neurotransmitter acetylcholine (ACh) in the cortical and hippocampus areas. Thus, ACh level elevation is one of the main goals of current pharmaco-therapeutic strategies for decreasing progression of AD. Based on the aforementioned findings, this article provides an overview of the latest progress in the development of powerful novel AChE inhibitors.

DOI

10.21608/ths.2025.344858.1003

Keywords

AChE inhibitors, Neuroinflammation, Alzheimer's disease

Authors

First Name

Fady

Last Name

H. Fayek

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Gesr El Suez st, PO 11786, Cairo, Egypt

Email

habib.fady@yahoo.com

City

-

Orcid

-

First Name

Hadeer

Last Name

K. Moftah

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Gesr El Suez st, PO 11786, Cairo, Egypt

Email

hadeerkhaled.mostafa@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Mai

Last Name

H. A. Moussa

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Gesr El Suez st, PO 11786, Cairo, Egypt

Email

mhatem@ecu.edu.eg

City

-

Orcid

-

First Name

Eman

Last Name

Z. Elrazaz

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Cairo 11566, Egypt

Email

eman_elrazaz@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

S. Kamel

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Gesr El Suez st, PO 11786 Cairo, Egypt Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University,

Email

ahmed.seifeldin@pharma.cu.edu.eg

City

-

Orcid

-

First Name

Deena

Last Name

S. Lasheen

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Cairo 11566, Egypt

Email

deenalasheen@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Hanan

Last Name

H. Georgey

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Gesr El Suez st, PO 11786, Cairo, Egypt Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr

Email

hanan.hana@pharma.cu.edu.eg

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

53796

Issue Date

2025-02-01

Receive Date

2024-12-21

Publish Date

2025-02-01

Page Start

1

Page End

24

Online ISSN

3009-7150

Article File

THS_Volume 1_Issue 1_Pages 1-24.pdf

PDF . 898.6kB

Link

https://thsj.journals.ekb.eg/article_411864.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411864

Order

411,864

Type

Review Article

Type Code

3,343

Publication Type

Journal

Publication Title

Translational Health Sciences

Publication Link

https://thsj.journals.ekb.eg/

MainTitle

Acetylcholine Esterase Inhibition in Alzheimer's Therapy: Spotlight on Quinzolinone Derivatives

Details

Type

Article

Created At

25 Feb 2025