413005

Elevating Alzheimer's Diagnosis based on Attention-Guided MRI Feature Fusion

Article

Last updated: 25 Feb 2025

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Abstract

The complicated pathophysiology of Alzheimer's disease (AD), which can occasionally be inherited, is typified by the loss of synapses and neurons as well as the appearance of neurofibrillary tangles and senile plaques. For treatment or prevention to be effective, early detection is essential, especially in high-risk patients. This work offers a multi-model feature fusion method based on the attention mechanism as a novel way to classify Alzheimer's disease. The ADNI dataset was first used to test many pre-trained models, and the top three performances were chosen for additional testing. We created an attention-based feature fusion module to efficiently combine features from three different modalities. Our tests showed that merging features without the attention mechanism results in a significant decline in performance (accuracy=82%). However, implementing the attention mechanism before the fusion process significantly enhanced performance, with 99.31% accuracy in classifying Alzheimer's disease into five stages. Motivated by these outcomes, we expanded our approach to classify the disease into four and three stages, with 98.29% and 99.43% accuracies, respectively. Our results demonstrate how well the multi-model features with the attention mechanism work to improve Alzheimer's disease classification.

DOI

10.21608/ijt.2025.350559.1075

Keywords

Alzheimer's disease, Deep learning, attention mechanisms, MRI

Authors

First Name

A. M.

Last Name

Elassy

MiddleName

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Affiliation

1 Electronics and Communications Engineering Department - Faculty of Engineering – Mansoura University – Mansoura – Egypt

Email

ayah_elassy@mans.edu.eg

City

Mansoura

Orcid

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First Name

Hanan. M.

Last Name

Amer

MiddleName

-

Affiliation

Electronics and Communications Engineering Department - Faculty of Engineering – Mansoura University – Mansoura – Egypt

Email

hanan.amer@yahoo.com

City

-

Orcid

-

First Name

H.M.

Last Name

Ibrahim

MiddleName

-

Affiliation

Assistant Professor- Faculty of Computers and Information Systems -Egyptian Chinese University-Cairo - Egypt

Email

hegazibrahim@gmail.com

City

-

Orcid

-

First Name

M.A.

Last Name

Mohamed

MiddleName

-

Affiliation

Electronics and Communications Engineering Department - Faculty of Engineering – Mansoura University – Mansoura – Egypt

Email

mazim12@mans.edu.eg

City

-

Orcid

-

Volume

05

Article Issue

01

Related Issue

52787

Issue Date

2025-01-01

Receive Date

2025-01-05

Publish Date

2025-01-01

Page Start

1

Page End

20

Online ISSN

2805-3044

Link

https://ijt.journals.ekb.eg/article_413005.html

Detail API

http://journals.ekb.eg?_action=service&article_code=413005

Order

413,005

Type

Original Article

Type Code

2,522

Publication Type

Journal

Publication Title

International Journal of Telecommunications

Publication Link

https://ijt.journals.ekb.eg/

MainTitle

Elevating Alzheimer's Diagnosis based on Attention-Guided MRI Feature Fusion

Details

Type

Article

Created At

25 Feb 2025