Background: Chest tube is a widely applied therapeutic postsurgical intervention in respiratory and cardiothoracic care. The chest tube can be a life-saving intervention for children with pneumothorax, effusions, and hemothorax. It is however associated with significant morbidity and mortality. Aim: This study aimed to determine the impact of social media-based training program on nurses' performance in caring children with chest tube. Research design: A quasi-experimental design was utilized to achieve the aim of this study. Setting: The research was conducted at the Pediatric Chest Intensive Care Unit affiliated with Beni Suef University Hospital, Egypt. Subject: A convenient sample included all (50)   nurses who worked in the previously selected setting. Tools: Tool I: Nurses' personal data, Tool II: Nurses' knowledge and Tool III: Nurses' practices observation checklist (pre and post). Results: This study revealed a statistically significant improvement in nurses' knowledge and practices respectively pre and post-social media-based teaching. Conclusion: The current study concluded that social media-based teaching positively improves nurses' knowledge and practices in caring children with chest tubes. Recommendation: Provide continuous in-service training for nurses caring for children with chest tubes in different healthcare settings.