Egyptian museums, which are famous for their rich cultural heritage and historical artifacts, are vital institutions that contribute significantly to the country's tourism industry and cultural identity. But in recent years, the world has witnessed the devastating impact of pandemics on various aspects of society, including the cultural sector. Museums, in particular, have been affected by these crises. The COVID-19 pandemic, in particular, has exposed museums to sudden disruptions, leading to lockdowns, reduced visitor numbers, economic crises, and the loss of many museum professionals. The research paper highlights the importance of improving museums' preparedness for epidemics through a theoretical study of the chronological sequence of epidemics that passed through Egypt to know their impact on society and the precautionary precautions followed in museums, followed by an analytical study that proposes a checklist of precautionary precautions followed in museums to enhance their resilience in the face of future epidemics to mitigate their impact on cultural institutions. Followed by an analytical study of The Royal Carriages Museum, which was opened during the COVID-19 pandemic, to assess the museum's ability to adapt to epidemics and crises.