Background: Some severe complications among patients undergoing general anesthesia may be related to poor visualization of tracheal structures. Subjectively, the bronchoscopic view obtained via a laryngeal mask airway (LMA) seems to be better than that obtained with an endotracheal tube (ETT). The quality of ventilation and airway-related complications are also reported. This may cause oxygenation impairment and further contribute to postoperative pulmonary complications. Assessing these complications is crucial for optimizing patient care. The aim was to evaluate the effect of educational guidelines on nurses' knowledge regarding airway risks and complications and to decrease patients' airway risks and complications by using a laryngeal mask and endotracheal tube. Research design: To complete this study a quasi-experimental research design was used. Setting: The study was conducted in the Intensive care unit at Sohag University Hospital. Sample: A convenient sample of 50 nurses who worked at the previously selected setting and 50 patients undergoing surgical operation was included within six months. Tools: Tool (I) Nurses' personal data assessment sheet, Tool (II): Nurses' knowledge about risk factors assessment sheet, Tool (III): Nurses' knowledge about complication assessment sheet, Tool (IV): Patients assessment questionnaire. Results: The result of the current study revealed that there were statistically significant differences and improvements were observed between nurses' knowledge mean scores after one month of the educational guidelines application. Conclusion: The application of educational guidelines regarding airway risks and complications for patients using laryngeal masks and endotracheal tubes has positive effects on improving patients' knowledge. Also, has a significant effect on decreasing the frequency of risks and complications of the Laryngeal mask airway and endotracheal tube. Believe that the laryngeal mask has fewer risks and complications than the endotracheal tube. Recommendations: Preparing patients before surgery and giving patients health education. Providing nurses with continuous in-service training programs that help increase their knowledge.