Since its establishment in 1925, the Faculty of Science, the Egyptian University (currently Cairo University) has achieved remarkable success in its pioneering role within the Egyptian society, demonstrated by a series of accomplishments that persist to this day. This article aims to highlight several significant contributions of the Faculty of Science during the second quarter of the 20th century. The success of the faculty during this period was achieved through sound planning, intellectual leadership, and diligent efforts in various academic activities. Our research relies primarily on documented information from the faculty's annual reports for an extended period, as well as relevant details from Born-Brimble's related article, complemented by available publications and diverse online sources.