Background: Electronic hookah smoking is one of the most avoidable risk factors for non-communicable diseases. It is also seen as a starting point for addiction. Pender's health promotion model is used to increase students' level of well-being and enhance preventive behaviors to prevent complications and subsequent effects of electronic hookah smoking. Aim:  To evaluate the effect of educational program about electronic hookah smoking for male university students based on Pender's Health Promotion Model. Research design: A quasi-experimental design was used. Setting: This study was conducted at 6 faculties of Sohag University including faculty of Education, Social service, Arts, Law, Archaeology and Commerce. Sample: A convenience sample of 600 male university students was selected. Tools: Two tools were used in this study. Tool one: A structured interviewing questionnaire which consisted of the following parts: a) demographic characteristics of studied students. b) Knowledge of studied students about electronic hookah smoking. Tool two: Pender's health promotion model. Results: The current study showed that only 10 % of studied students had good knowledge at pre-educational program about electronic hookah smoking which improved to 86% at post program. Additionally, according to Pender's health promotion model, 25.7% of studied students had good beliefs at preprogram which increased to 87.8% of them had good beliefs at post-program. Conclusion: The study findings revealed to improvement in students' knowledge and beliefs after implementation of educational program about electronic hookah smoking Recommendations: Developing health educational program to increase awareness for male university students about prevention of electronic hookah smoking.