Background: Thyroid disorders are among the most prevalent endocrine issues in pregnant women and can have a major negative impact on the health of both the mother and the fetus. Aim: This study aims to evaluate the effect of nursing educational programs on pregnant women's health from thyroid disorders. Design: A quasi-experimental research design was used to conduct this study. Setting: The research was conducted in an outpatient clinic in obstetrics and gynecology at Kafr El-Sheikh University Hospital. Sample: A purposive sample of 120 pregnant women with thyroid disorders was sorted into a control group and a study group based on specific criteria. Tools: One tool was utilized in this research. The interview questionnaire is divided into four parts: demographic characteristics, medical history of pregnant women with thyroid disorders, pregnant women's knowledge, and pregnant women's self-reported practices. Results: Shows that, 88.2 %  in the study group had poor knowledge, 91.6% in the control group had poor knowledge before implementation of the program improved to 91.6 % good knowledge post-program, and  75.0%  slight decline in the follow-up program in the study group, compared to no improved the total knowledge in the control group. 86.6%  poor knowledge in the post-program and  93.4 %   in the follow-up. Regarding total self-reported practice scores level pre-program r=0.6 in the study group and r=0.5 in the control group for the program improved to r=0.7 in the study group after implementing the program and r=0.6 in the control group post-program. Also, r=0.8 was found in follow-up in the study group, and r=0.6 was found in the control group after program implementation. There was a highly statistically significant difference between the two groups in post-test and follow-up, where p<0.001.Conclusion: A highly statistically significant relation between the total knowledge scores,  total self-reported practice scores, and demographic characteristics  pre-, post, and following the implementation of the educational program in the study group, with a significance level of P <0.001 compared to the control group with no improvement in knowledge and self-reported practice.Recommendations: Pregnant women with thyroid disorders should have regular follow-up appointments, especially if they have a history of thyroid problems. Routine screening for thyroid function tests in the antenatal clinic is important to enhance pregnant women's health.