Background: Pharmacovigilance (PV) and patient safety are two essential aspects of healthcare. In order to ensure proper use of medications which enhances patient safety, PV systems are therefore more important than ever. Aim: To evaluate the role of implementing pharmacovigilance program for staff nurses and its effect on patients'safety. Methods: The design was Quasi-experimental. Three tools used for data gathering namely; Pre/Post-test Knowledge Assessment Questionnaire, Staff Nurse Pharmacovigilance Attitude Questionnaire and Patient Safety Scale. Results: Nurses improved knowledge from zero good level preprogram to more than three-quarters good level immediate program. Also, improved from negative attitude level toward pharmacovigillance preprogram to positive attitude immediate after program. As well as, patients'safety improved to moderate level immediate and post program than preprogram. In addition, highly statistically significant relationship among knowledge of nurses, attitude besides patients'safety pre, immediate and post program. Conclusion: Patients'safety improves after applying pharmacovigilance program for staff nurses. Recommendations: Improving awareness among other healthcare providers, particularly those in nursing and pharmacy fields who work closely with patientsand nurse managers should regularly assess and monitor patients'safety facets among nurses to achieve safe and healthy environment for patients.