This research was carried out on 17-year-old "Le-Conte" pear trees that were grafted on Pyrus communis and were growing in loamy sand soil with drip irrigation over the two seasons of 2021 and 2022, to investigate the effects of two irrigation rates ( 75 and 100% of crop water requirement), two emitter discharges (4 and 8 L/h) and anti-stress substances (wuaxal amino and free sal) and the interaction among them on vegetative growth and leaf mineral contents. Results showed that the higher irrigation rate 100% and emitter discharges of 8L/h give the highest vegetative growth values. On the other hand Mixing wuxal + free sal was the promising one concerning to vegetative growth parameters enhancement. On other side The combination of CWR at 100% + discharges of 8 + free sal recorded the highest N and Fe. Applying of CWR at 100% + discharges of 8L/h + wuaxal recorded the highest P and Mg. applying of CWR at 75% + discharges of 8L/h + free sal recorded the highest K and Zn. Applying of CWR at 75% + discharges of 4L/h + (W+F) recorded the highest of Ca values. Applying of CWR at 75% + 4L/h + wuxal recorded the highest Mn values. On the other side the lowest proline acid values were attributed to applying of CWR at 100% + wuxal + discharges of 8L/h. While applying CWR at 75% + emitter discharges of 4L/h + free sal gave the lowest peroxidase values.