Background: Corona virus is one of the major pathogens that mainly target the respiratory system of humans. Aim: this study Aimed to assessing mother`s knowledge and practices of mother`s have children with covied19. Research design: Descriptive research design will be used to achieve the aim of this study. Study setting: the study will be conducted at El fayoum health insurance Outpatient clinics affiliated to El fayoum governorate. Subjects: A purposive sample of 200 (out of 1000 - 1200) mothers attending the previous mentioned setting.Tools of data collection: A structure Interview Questionnaire Sheet: consists of four part: Part 1:  Socio-demographic characteristics of children and their mothers. Part II: child past history and health status. Part III: knowledge of mothers about covied 19.Part IV: Mothers reported practices about covied 19 include 4 part: 1-General procedures. 2-Home isolation.3-Clean and disinfection 4-Practice to increase child immune system: Results: 72.0% of the studied mothers were unsatisfactory level of total knowledge about covid-19 disease. While, 28.0% of them were satisfactory level and 78.0% of the studied mothers had inadequate practices toward the covid-19 disease. While, 22.0% of them had adequate practices. Moreover, there is statistically significant relation between the total knowledge of the studied mothers and health history of children and infectious diseases at (P= < 0.05). While, there is no statistically significant relation with their history from genetic diseases, birth defects, previous operations, problems during birth and chronic disease at (P= > 0.05) and  there is highly statistically significant relation between total knowledge of the studied mothers and their total reported practices toward covid-19 disease at (P < 0.01). Conclusion: Less than three quarters of the studied mothers were unsatisfactory level of total knowledge about covid-19 disease. While, more than one quarter of them were satisfactory level, and more than three quarters of the studied mothers had inadequate practices toward the covid-19 disease. While, less than one quarter of them had adequate practices regarding covied19. Additionally there is statistically significant relation between the total knowledge of the studied mothers and health history of children and infectious diseases. While, there is no statistically significant relation with their history from genetic diseases, birth defects, previous operations, problems during birth and chronic disease.  Also there is highly statistically significant relation between total knowledge of the studied mothers and their total reported practices toward covid-19 disease. Recommendation: The study highlights the need for an educational program, workshops, and videos \booklets conducted for mothers to improve their knowledge and practice for their children regarding COVID-19 pandemic. Increase awareness and improve knowledge related to COVID-19, health regulators should enhance women's knowledge by using multiple communication approaches, digital, paper, social media, phone messages, etc