Background:Alzheimer's disease is a neurological disease that progresses over time. It is defined by the presence of both extracellular amyloidbeta (Ab) plaques, which are primarily made up of deposited Ab, and intracellular neurofibrillary tangles, which are made up of hyperphosphorylated and abnormally phosphorylated tau protein.Aim:This study aimed to investigate the role of Punica granatum and Persea americana extracts as an agent to decrease neurodegenerative effects of AlCl3 toxicity in male rats..Methods:42 male rats were divided in to seven experimental groups . G1 is the negative control group, and G2 is the positive control group.,G3,G4 and G5 received Alcl3(17 mg/kgb.w.)oral daily for one month and treated with Punica granatum extract (40 mg/kg b.w.),Persea americana extract (33.3 mg/kg b.w.) for three months and reference drug aricept(0.4 mg/kg b.w.)2 weeks of taking it orally respectively.Results: The mean level of dopamine in brain tissue in positive control decreased signeficantly compared to negative control. Brain caspase 3 and DNA fragmentation were significantly elevated.The treatment of punica granatum and persea americana extracts alleviated the adverse effect of AlCl3 in the treated groups and enhanced the dopamine level and declined apoptotic markers. conclusion :Punica granatum and Persea americana has an impact to minimize neurodegenerative effect of AD.