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240632

Chromatographic spectroscopic technique for the determination of simvastatin in pharmaceutical formulations

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Analytical chemistry

Abstract

An RP-HPLC method for quickly and accurately measuring simvastatin in pure and capsule dosage forms was quickly and accurately made. Guidelines from the International Conference on Harmonization (ICH) were used to make sure the procedure worked. 4.6 mm x 250 mm Arcus EP-C18 Arcus EP-C18, with KH2PO4 solution (0.05 M) and methanol (20:80 V/V), at pH 5, as a mobile phase, at a flow rate of 1 mL/min. The HPLC system used the 240 nm UV system to find out what was going on. In order to do the analysis, a 10-minute run time was utilized. The linear method was (R2 =0.9990) at concentrations of (2 to 10 µg/mL), this method was linear, precise (inter-day RSD values were less than 1%), accurate (Range Recovery was 95±112% to 98.382±0.101%), specific, and strong. It was based on linearity and regression to figure out the detection and quantification limits. They were 0.85 µg/mL and 2.01 µg/mL, respectively. The proposed technique was being tested to be correct, precise, and quick when it came to simvastatin in bulk and capsule dosages, so it was a good idea.

DOI

10.21608/ejchem.2022.117534.5300

Keywords

simvastatin drug, HPLC-UV analysis of simvastatin, Statins group

Authors

First Name

Ali K.

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq.

Email

-

City

-

Orcid

-

First Name

H. N. K.

Last Name

AL-Salman

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq.

Email

hussein.khalf@uobasrah.edu.iq

City

basrah

Orcid

-

First Name

Hussein H.

Last Name

Hussein

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq.

Email

-

City

-

Orcid

-

Volume

66

Article Issue

2

Related Issue

39241

Issue Date

2023-02-01

Receive Date

2022-01-21

Publish Date

2023-02-01

Page Start

13

Page End

19

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_240632.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=240632

Order

240,632

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Chromatographic spectroscopic technique for the determination of simvastatin in pharmaceutical formulations

Details

Type

Article

Created At

30 Dec 2024