Background: Climate change is one of the major global health issues that have quickly moved to the top of the agenda. Its effects can be severe, impacting people not just physically but also mentally and socially. Nurses must be aware of its consequences and advocate for eco-friendly practices that will mitigate its harmful effects on health. Aim: To assess nursing students' knowledge and reported practices regarding health effects of climate change in Sohag City. Study design: A descriptive cross-sectional research design was used. Setting: The study was conducted at the faculty of nursing, technical health & technical nursing institutes in Sohag City. Sampling: A systematic random sample consists of 286 nursing students. Tools: Tool I included two parts; part one included demographic characteristics and part two included a questionnaire to assess the nursing students' knowledge regarding the health effects of climate change. Tool II assesses the nursing students' reported practices regarding climate change. Results: 82.5% of nursing students had poor knowledge, and 67.1% of them had unsatisfactory practices regarding climate change. Conclusion: There was a serious lack of information among nursing students about the phenomenon of climate change. Also, about two-thirds of them had unsatisfactory reported practice scores. Recommendations: Implement an educational program to raise nursing students' awareness about climate change and its adverse health effects.