Background: Although 95% of pressure ulcers are preventable, elderly patients who suffer from them have a mortality risk that is two to six times higher than that of a patient whose skin is intact. Aim: To assess knowledge of elderly caregivers toward pressure ulcer. Design: Descriptive research design. Setting: Sohag Governorate Hospitals: Sohag General Hospital and Sohag Teaching Hospital are located in the Western direction, while Akhmim Central Hospital and Sohag University Hospital are located in the Eastern direction.Sample: Stratified random sample was used to select two hospitals from each direction, then an appropriate purposive sample used to select the elderly patients and their caregivers during six months. Tools: Tool (1): Structured interview questionnaire: it includes two parts: Part I: Demographic data and medical history of elderly. Part II: Demographic data of elderly caregivers. Tool (2): Elderly caregivers' knowledge about pressure ulcer structured questionnaire: it includes two parts: Part I: Caregivers'  knowledge toward pressure ulcer questionnaire. Part II: Caregivers' knowledge of pressure ulcer care and prevention structured questionnaire. Results: In our study, 29.0% of the elderly caregivers had satisfactory knowledge about pressure ulcers, compared to 71.0% who had unsatisfactory knowledge. Conclusion: The knowledge that elderly caregivers possessed about pressure ulcers was inadequate. The level of knowledge about pressure ulcers among the elderly caregivers under study differs significantly from demographic information in a highly statistically significant way. Recommendation: Establishing training and educational program about pressure ulcer for elderly people and their caregivers.