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323409

Mitigation of Aluminum Chloride-Induced Alzheimer's disease by blueberry in rat model

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Section D: Clinical Pharmacy and Pharmacology

Abstract

Alzheimer's disease (AD) is a global chronic neuro-disorder disease categorized by the lack of cognition and memory. Here, the present exploration was intended to reveal the ameliorative properties of Blueberry (BB) against aluminum chloride (AlCl3)-provoked neurobehavioral and pathological changes in AD animals. Eighteen male rats were allocated into three groups. Control group; rats received saline, AlCl3 group; rats received AlCl3 (70 mg/kg/day orally) for 28 days and AlCl3 + BB group, rats treated with BB (0.4 mg/kg/day, orally) for 28 days, 1 h after the injection of AlCl3. At the end of the experiment, the behavioral tests (open field, Morris water maze, and novel object) were done as well as brain was separated for biochemical, and histological measurements. Treatment with BB amended changes in body weights and biochemical and histopathological alterations induced by AlCl3. Moreover, BB significantly improved the behavioral impairments caused by AlCl3. The current study revealed that BB may contribute to protecting the brain from Alzheimer's disease caused by aluminum intoxication.

DOI

10.21608/erurj.2023.212817.1031

Keywords

Alzheimer’s disease, Blueberry, cognitive impairment, Oxidative Stress, Inflammation

Authors

First Name

Laila

Last Name

Ramadan

MiddleName

A

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

laila-ramadan@eru.edu.eg

City

-

Orcid

0000-0002-3637-6312

First Name

Manar

Last Name

Daidamoony

MiddleName

A

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

manar-didamoony@eru.edu.eg

City

-

Orcid

-

First Name

Ali

Last Name

Elgindy

MiddleName

M

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

ali-elgindy@eru.edu.eg

City

-

Orcid

-

First Name

Aya

Last Name

Mustafa

MiddleName

M

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

aya-mustafa@eru.edu.eg

City

-

Orcid

0000-0002-9909-6318

First Name

Esalm

Last Name

Hassan

MiddleName

-

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

eslam-hassan@eru.edu.eg

City

-

Orcid

0000-0003-2975-6437

First Name

Hanaa

Last Name

Abdel-Rahman

MiddleName

M

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

hanaa-ebido@eru.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Atwa

MiddleName

Mohamed

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt

Email

ahmed-atwa@eru.edu.eg

City

-

Orcid

0000-0001-8580-4179

Volume

2

Article Issue

4

Related Issue

44159

Issue Date

2023-10-01

Receive Date

2023-05-31

Publish Date

2023-10-01

Page Start

682

Page End

698

Print ISSN

2812-6211

Online ISSN

2812-622X

Article File

ERURJ_Volume 2_Issue 4_Pages 682-698.pdf

PDF . 679.7kB

Link

https://erurj.journals.ekb.eg/article_323409.html

Detail API

https://erurj.journals.ekb.eg/service?article_code=323409

Order

323,409

Type

Original Article

Type Code

2,445

Publication Type

Journal

Publication Title

ERU Research Journal

Publication Link

https://erurj.journals.ekb.eg/

MainTitle

Mitigation of Aluminum Chloride-Induced Alzheimer's disease by blueberry in rat model

Details

Type

Article

Created At

29 Dec 2024