Background: Scalp cryotherapy is beneficial in minimizing hair loss in patients with cancer receiving chemotherapy successfully administered under special instructions, and additionally promotes hair regrowth. This study aimed at evaluating the effect of Instructions on promoting Hair Regrowth in cancerous patients undergoing chemotherapy and using Scalp Cryotherapy. Design: The study methodology follows a quasi-experimental approach. Setting: The Hope Cure Cancer Centre in Mansoura City, Egypt, is the site of the current study. Sample: 100 adult female cancer patients who were scheduled to receive chemotherapy and were randomly assigned to one of two equal groups (the control group or the intervention group). Tools: Tool 1, a structured interview questionnaire, was used to evaluate demographic information, health history, current health status, and side effects of scalp cooling. Tool II; Modified WHO Hair Loss Scale to examine hair loss measurements before and after each chemotherapy cycle. Tool 3, Hair Re-Growth Scale which measures the rate of hair growth and loss. Results: By the second follow-up month, 52% of women in the intervention group had thick hair regrowth, indicating very good progress, as compared to just 12% in the control group, with a statistically significant difference. Conclusion: Cancer patients who adhered to specialized instructions observed that scalp cryotherapy was beneficial in preventing chemotherapy-induced hair loss. Recommendation: Provide an online consultation program for those interested in learning more about scalp cryotherapy, how to manage its adverse effects, and what influences hair regeneration.