Carica papaya is an important economic plant that has many nutritional
advantages and, remarkable medicinal purposes including treatment of a wide
range of illnesses. Thus, the purpose of this study was to determine how well
carica papaya leaf extract mitigates the effects of paracetamol on blood
biochemical markers and oxidative damage of rats. Six groups each group
consists of six male albino rats, weighing 150 ± 15 g, were created. Group
one consisted of a healthy group; Group two consisted of rats given an
ethanol papaya extract (100 mg/kg body weight); Group three consisted of
rats given an ethanol papaya extract (200 mg/kg body weight).Rats in group
four were given paracetamol (2g/kg b.wt). Rats in group five received a
pretreatment of carica papaya extract (100 mg/kg body weight) and a 30-
minute paracetamol treatment. Rats in group six received 200 mg/kg body
weight of carica papaya extract as a pretreatment before receiving
paracetamol. The experiment continued for two months. The group receiving
paracetamol showed a significant increase in blood markers, including urea,
creatinine, AST, ALT, and ALP. As a result of these findings, preventing
oxidative stress caused by paracetamol was achieved through pretreatment
with carica papaya extract which improved antioxidant enzymes (CAT and
SOD). According to these results, paracetamol-induced liver and kidney
damage can be prevented by the hepato-protective and nephroprotective
actions of Carica papaya leaf extract. lowering oxidative stress, boosting
antioxidant defenses, encouraging liver cell regeneration, and regaining
normal liver and kidney function, helps in mitigating liver and kidney
damage.