Background: Since organizational flexibility is a global necessity, it has become more and more important in recent years, as demonstrated by the improvements hospitals have made to better explore new opportunities for adapting to or preparing for new events, as well as by increasing employment opportunities, raising salaries, and creating a culture that discourages rapid employment and layoffs. These actions have left a large class of employees feeling secure in their jobs. Aim: To assess organizational flexibility and job security practices in healthcare settings; nurses' perspectives. Settings: This study was conducted in medical units (24), surgical units (17), critical care units (4) at Alexandria Main University Hospital and Medical Research Institute Hospital in medical units (10), surgical units (5), critical care units (4), as the two hospitals are the largest hospitals, contained a large number of beds and staff nurses with different qualifications. Subjects: convenience sample of 284 staff nurses with 6 months experience and more who worked in the previously mentioned units and available at the time of data collection. Tools: Two tools were used in this study Namely; Organizational flexibility questionnaire and job security questionnaire. Results: The study showed there was significant positive high correlation between organizational flexibility and job security where (r = 0.442, p = 0.000*), and significant positive high correlation between employee flexibility, social desirability and job security where (r = 0. 440 and 0.506, p = 0.000*). Recommendations: For the health care organization, setting up regular staff meetings and open dialogues to learn about their needs and issues and to help them participate in decisions affecting their workplace and patients in order to enhance their sense of fulfillment, self-worth, intention to stay, and job security; and for the staff nurses, setting up manager-only training sessions and staff meetings to strengthen managers' capacity to consider employees' requests for job security and flexibility.