Background: Health care providers are insecure to COVID-19 risk due to open exposure and working at different outpatient clinics. Aim: To assess health care providers' practices of the WHO protocol for infection prevention and control of COVID-19 in different outpatient settings. Design: A descriptive exploratory research design was utilized for this study. Settings: The present study was conducted at the African Center of Woman's Health, Alexandria and at the Medical Research Institute, Alexandria University. Subjects: A convenience sample of 40 health care providers in the above-mentioned settings was included in the study, 26 in African Center and 14 in Medical Research Institute. Tools: Two tools were used for the data collection: Tool (I): Health Care Providers' socio-demographic & clinical data, Tool (II): WHO protocol for infection prevention and Control Practices regarding covid19: Observational Checklist. Results: All health care providers had unsatisfactory overall level of practice. Mean ±SD of nurses' practice was higher than physicians' practice (190.4±14.13 and, 165.9±14.34 respectively), with a statistical of significant difference between them (X2= NA). Conclusion: The majority of health care providers had unsatisfactory level of overall practice regarding WHO protocol for infection prevention and control of covid-19 in different outpatient clinics. Recommendations: In-service education program for health care providers to update their knowledge and practices concerning WHO protocol, modify and repair the infrastructure of health care facilities according to WHO protocol, and repetition of the study on large prospect sampling.