Background: Women die as a result of complications during and following pregnancy and childbirth. Most of these complications develop during pregnancy and most are preventable or treatable. Aim: To assess postpartum nurse's compliance with safety measures. Settings: The study will be carried out at the all postpartum units in five hospitals in Alexandria. The Tool one: Nurses knowledge about safety measures during postpartum period. This tool divided into two parts: The Part I: Socio-demographic data structured Questionnaire: It will include basic data of the study. The Part Two: Nurses knowledge about safety measures during postpartum period. Tool two: Postpartum nurses' compliance with Safety measures guidelines observational checklist: This tool will be adapted by the researcher from ministry of health and WHO. Results: The study revealed that more than half (55%) of the studied nurses had poor score compared to 41% of them had fair score and only 4% of the studied nurses had good score of knowledge. It was observed that more than half on the studied nurses (53.00%) had poor total score of compliance while 47.00% of them had fair score Conclusion: The study clarified that there is no statistically significant relationship between the studied nurses total score of compliance and their knowledge regarding safety measures during postpartum period. Recommendations: Reinforce regular supervision of nurses in the postpartum to ensure that they comply with patient safety measures.