Background: Compliance of nurses with patients' rights is a crucial human right because patients are one of the most vulnerable groups in society. The study aimed to assess nurses' compliance with patients' rights and their awareness of legal and ethical issues. Research design: A descriptive correlational research design was utilized. Setting: conducted at Liver University Hospital in Minia Governorate, Egypt. Sample: a convenient sample was included, in which the total number was (107 nurses). Tools: two tools were used: tool: a self-administrated questionnaire, and Tool: nurses' awareness about the legal and ethical issues in patient care. Results: There were more than half of the studied nursing (60.9%) had compliance with patients' rights, and more than two thirds (68.2%) had fair awareness level about legal and ethical issues occurring in the care of patients. Conclusion: there was a positive statistical correlation between total score of nurses' awareness regarding ethical issues occurring in care of patients with total score of nurses' compliance with patient's rights. Recommendations: implement an educational training program for nurses regarding patient's rights and ethical and legal issues