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391770

Increased CD3 immunostaining associated with high grade and tumor size in colorectal carcinoma

Article

Last updated: 28 Dec 2024

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Tags

Host response

Abstract

Background: Colorectal cancer lacks reliable prognostic biomarkers, complicating the differentiation between aggressive and indolent tumors. While CD3+ T lymphocyte infiltration generally correlates with improved prognosis and response to immunotherapy, its specific role in tumor aggressiveness is not fully understood. Objective: This study aims to assess CD3+ T cell infiltration in benign and malignant colorectal tissues and explore its potential association with clinical outcomes. Methodology: Immunohistochemistry was used to assess CD3+ T cell staining in the stromal tissue of benign (n=24) and malignant (n=80) colorectal samples. CD3+ T cell expression was then correlated with clinic pathological data such as grade and stage. Results: CD3+ T cell infiltration was significantly higher in colorectal carcinoma than benign tissues (p=0.007). A positive association was observed between CD3+ T cell immunostaining and high tumor grade (p=0.002), while a negative correlation emerged between CD3+ T cell immunostaining and tumor size (p=0.005). No significant relationship was identified between CD3+ immunostaining and lymph node involvement. Conclusion: CD3+ T cells might be involved in the aggressiveness of malignancy. Further research is needed to determine the significance of CD3+ T cells in colorectal carcinoma and its potential as a biomarker for cancer progression.

DOI

10.21608/ejmm.2024.331363.1364

Keywords

Colorectal carcinoma, CD3, Immunohistochemistry, Tumor grades, Tumor invasion

Authors

First Name

Oula

Last Name

Alalwany

MiddleName

-

Affiliation

Department of Medical Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 64001,Iraq

Email

aula.s.msc@utq.edu.iq

City

Thi-Qar

Orcid

-

First Name

Dhafer

Last Name

Alghezi

MiddleName

A.

Affiliation

Department of Medical Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 64001,Iraq

Email

dhafer.a.f.alghezi@bath.edu

City

-

Orcid

0000-0002-5450-6360

First Name

Rasha

Last Name

Aljawher

MiddleName

Q.

Affiliation

Department of Histopathology and Forensic Medicine, College of Medicine, University of Thi-Qar, Thi- Qar, 64001,Iraq

Email

rasha-k@utq.edu.iq

City

Nasiriyah

Orcid

-

First Name

Ali

Last Name

Harb

MiddleName

-

Affiliation

Department of Community Health Technologies, College of Health and Medical Technologies, National University of Science and Technology, Thi-Qar, Iraq

Email

ali.harb@nust.edu.iq

City

Nasiriyah

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-10-27

Publish Date

2025-01-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_391770.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=391770

Order

391,770

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Increased CD3 immunostaining associated with high grade and tumor size in colorectal carcinoma

Details

Type

Article

Created At

28 Dec 2024