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377480

Association of tumor necrosis factor-α gene polymorphisms with risk of non-alcoholic fatty liver disease: Systematic review with meta-analysis

Article

Last updated: 28 Dec 2024

Subjects

-

Tags

Genetics

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases that is affected by various environmental and genetic factors. The association between tumor necrosis factor-alpha (TNF-α) gene polymorphism in regions -308G/A (rs1800629) and -238G/A (rs361525) and susceptibility to NAFLD is controversial. Objective: This meta-analysis evaluated the association between different candidate TNF-α polymorphisms and NAFLD. Methodology: A systematic search was conducted on PubMed, Cochrane Library, and Egyptian Knowledge Bank accessing the following databases: Scopus, Web of science, EBSCO and Ovid, and EMBASE to retrieve all relevant studies published until March 29, 2023. Based on predetermined selection criteria, all eligible studies were included in the meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results: The systematic search revealed that five TNF-alpha polymorphisms were studied concerning NAFLD risk: TNF-α -1031(rs1799964), -857(rs1799724), -308(rs1800629), -238(rs361525), and -863(rs1800630), with the last three polymorphisms were eligible for meta-analysis.  Eleven studies with 1155 NAFLD cases and 1364 controls demonstrated the significant association between rs1800629 polymorphism and NAFLD under both the dominant model [OR = 1.27, 95% CI = 1.01–1.59, P = 0.04] and allelic contrast [OR = 1.26, 95% CI = 1.03–1.54, P = 0.02], with no significant association under heterozygous comparison. Considering the rs361525 polymorphism, meta-analysis including nine studies with 904 cases and 848 controls suggested significant association under each of the dominant model [OR = 1.76, 95% CI = 1.14–2.71, P =0.01], heterozygous model [OR = 1.77, 95% CI = 1.14–2.74, P = 0.01], and the allelic model [OR = 1.66, 95% CI = 1.31–2.44, P = 0.01]. However, no association was found between rs1800630 polymorphism and NAFLD risk. Conclusion: This meta-analysis suggested that TNF-α gene polymorphisms rs361525 and rs1800629, but not rs1800630, might be a risk factor for NAFLD.

DOI

10.21608/ejmm.2024.313265.1310

Keywords

Non-alcoholic fatty liver disease, Tumor necrosis factor-alpha, Polymorphism, Meta-Analysis, systematic review

Authors

First Name

Alaa

Last Name

Osman

MiddleName

A.

Affiliation

Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Egypt

Email

dr.alaaosman91@gmail.com

City

-

Orcid

0000-0002-9815-3384

First Name

Sally

Last Name

Elkhadry

MiddleName

W.

Affiliation

Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Egypt

Email

drsallywaheed@liver.menofia.edu.eg

City

-

Orcid

0000-0001-9305-3045

First Name

Gasser

Last Name

El-Azab

MiddleName

-

Affiliation

Hepatology Department, National Liver Institute, Menoufia University, Egypt.

Email

gelazab@gmail.com

City

-

Orcid

0000-0001-6776-1371

First Name

Laila

Last Name

Dorgham

MiddleName

Sh.

Affiliation

Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Egypt.

Email

lailadorgham@gmail.com

City

-

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-08-18

Publish Date

2024-10-01

Page Start

161

Page End

175

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_377480.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=377480

Order

21

Type

Review articles

Type Code

2,039

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association of tumor necrosis factor-α gene polymorphisms with risk of non-alcoholic fatty liver disease: Systematic review with meta-analysis

Details

Type

Article

Created At

28 Dec 2024