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323674

Kidney Transplantation with Modification of Induction Protocol with Infection Control Strategy during COVID-19 Era: Graft and Patients' Outcomes

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: With modifications to the induction techniques, policies against COVID-19 are strongly justified in kidney transplants. Objective: This study evaluated the efficacy of induction protocol modification with infection control strategy at the time of transplantation on renal graft and patient's outcome in the first 3-9 months post-renal transplant. Methodology: Retrospective pilot cohort research involved 24 patients who had liver-kidney or live-related kidney transplantation following the use of COVID-19 hospital transplantation management strategy. Total ATG dosage ranged from 3 mg/kg to 6 mg/kg depending on the patient's risk. Results: Post-transplant COVID-19 infection was detected in 16.6% (4 patients). 12.5% (3 individuals) had mild to moderate symptoms. Serum creatinine (2–2.5 mg/dl) was present in 8.3% of the individuals. 12.5% (3 patients) and 4.16% (1 patient) of COVID-19 infections occurred in the eighth or ninth week following kidney transplantation, with negative seroconversion occurring 10–14 days and 4–6 weeks, respectively, after the diagnosis. The COVID-19 result was a full improvement with increased steroids and decreased mycophenolate mofetil (MMF). The mortality was 0%. 95.8% (23 patients) had satisfactory graft function {Serum creatinine was (1.06–0.23 mg/dl)}. 4.16% (1 patient) had a residual blood creatinine level of 2.1 mg/dl after COVID-19 but didn't require dialysis. 4 patients (16.6%) had delayed graft function, and 2 patients (8.3%) with suspected rejection improved in less than a week without graft failure or the need for further treatment. Conclusion: Induction modification combined with effective infection control measures against COVID-19 is linked to positive renal graft and patient outcomes.

DOI

10.21608/ejmm.2023.323674

Keywords

outcomes, Infection control, induction modification, COVID-19

Authors

First Name

Magdy

Last Name

Elsharkawy

MiddleName

M.

Affiliation

Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo-Egypt.

Email

magdi35@hotmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Emara

MiddleName

A.

Affiliation

Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo-Egypt.

Email

ahmed_emara@med.asu.edu.eg

City

-

Orcid

-

First Name

Abdelrahman

Last Name

Elbraky

MiddleName

A.

Affiliation

Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo-Egypt.

Email

aelbraky@gmail.com

City

-

Orcid

-

First Name

Shaimaa

Last Name

Abdallah

MiddleName

Z.A.

Affiliation

Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo-Egypt.

Email

nanajettan@gmail.com

City

-

Orcid

-

Volume

32

Article Issue

4

Related Issue

42768

Issue Date

2023-10-01

Receive Date

2023-10-29

Publish Date

2023-10-01

Page Start

111

Page End

116

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 4_Pages 111-116.pdf

PDF . 364.6kB

Link

https://ejmm.journals.ekb.eg/article_323674.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=323674

Order

323,674

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Kidney Transplantation with Modification of Induction Protocol with Infection Control Strategy during COVID-19 Era: Graft and Patients' Outcomes

Details

Type

Article

Created At

28 Dec 2024