Background: Nursing interventions throughout paracentesis procedure in professional way can be considered the main factor to achieve a safe and successful procedure for ascetic patients. The highly experienced patient preparing, positioning, and monitoring before, during and after paracentesis is very important and vital to avoid expected complications. Aim: assess nurses' performance regarding care of liver cirrhotic patients' undergoing paracentesis. Design: Descriptive exploratory research design was used. Setting: Internal medicine, emergency and intermediate, intensive care units of Liver and Gastroenterology Hospital in Elminia. Subject: A convenient sample of all available nurses (60 nurses) from both genders working in previous mentioned settings. Tools: Two tools were used for data collection. Tool (I): Nurse's self-administrated interview questionnaire , and Tool (II): Practical observational checklist. Results: The study results reported that (41.7%, 53.3%, 26.7%, & 23.3%) of studied nurse had unsatisfactory level of knowledge about liver function tests, liver cirrhosis, ascites and paracentesis, respectively. Also, (36.7%, 31.7%, & 13.3%) of them had in competent level of practice at (pre, during, and post paracentesis procedure throughout care of liver cirrhotic patient, respectively. Additionally, there was a statistically significant relation between the demographic characteristics (educational level, working unit, and years of experience) and the total level of knowledge and practice regarding care of liver cirrhotic patient's undergoing paracentesis. Conclusion: There was a highly statistically significant correlation between the total knowledge and practice regarding care of liver cirrhotic patients' undergoing paracentesis. Recommendations: upgrade nurses' knowledge and skills throughout in-service training program with frequently evaluation about paracentesis care.