Background: Palliative care is a crucial part of integrated people-centered health services that attempts to reduce a patients' suffering and improve their life during a chronic disease from the time of their life-threatening diagnosis. Nurses play a crucial role in caring for Palliative and End-of-Life patients and their families as part of the care team Therefore; nurses need a set of various competencies to provide high-quality palliative care. Aim: To assess Perceived Competencies toward Palliative and End of Life Care among Nurses' in Beni-Suef University Hospital. Design: Descriptive research design. Sample: A convenience sample was used to choose 104 nurses setting: The study was conducted in out-patient clinic Beni-Suef University Hospital, Egypt. Tools: One tool was used to collect the data it consisted of five parts: part I concerning with Socio demographic data for nurses ‘part II: Participants' knowledge questionnaire. part III: Attitude toward Palliative and End of Life Care part IV: Reported practice part V: perceived competencies. Results: The study result revealed that, 27.9% of nurses had good total Knowledge scores, 23.1% of nurses had negative total attitude scores, 21.2% of nurses had Unsatisfactory total practices scores, 12.5 % of nurses had Law Competent total competency scores. Conclusion: No significant relation between demographic characteristics and total knowledge level, total reported practice, total attitude, total competency among the studied sample except income with total knowledge level and place of residence with total attitude level among studied sample. Recommendations: Adopting and application of competency-based program in different health care setting