Background: Clinical Reasoning is a complex process that involves a combination of knowledge, skills, and experience. It is important for nurses to work effectively as part of a healthcare team. Aim: Was to assess nurse educators' knowledge and perception about clinical reasoning at nursing technical institutes. Design: A descriptive research design was used. Setting: Three nursing technical institutes included Nursing Technical Institute in Cairo University in Giza. Nursing Technical Institute at the Health Technical Institute in Imbaba in Giza. In addition, all Institutes of the General Organization for Hospitals, and Educational Institutes in Cairo, and Giza that contains 10 nursing technical institutes. Subjects: All nurse educators in previous settings were included (n=160). Two tools were used for collecting data. 1st tool was Nurse Educators' Knowledge about clinical reasoning questionnaire and 2nd one was Nurse Educators' perception about clinical reasoning questionnaire. Results: 68.8% of nurse educators had unsatisfactory level of total knowledge about clinical reasoning. In addition, 65.4% of nurse educators had positive perceptions about clinical reasoning. They also perceived role of nurse educators in clinical reasoning positively. Conclusion: more than two-thirds of nurse educators had an unsatisfactory level of knowledge about clinical reasoning. Additionally, the nurse educators had positive perceptions about clinical reasoning and their perceived role in clinical reasoning. Recommendation: Provide training program for nurse educators about clinical reasoning to help them to be able to apply it. Also, further studies to examine the impact of clinical reasoning training on nursing students' competencies.