In cancer photodynamic treatment (PDT), curcumin can be used as a photosensitizing agent in addition to its anticancer therapeutic properties. However, curcumin's limited therapeutic value in cancer treatment is due to its poor bioavailability and associated pharmacokinetics. Due to its strong anticancer effects, curcumin was prepared as a nanoemulsion with an average particle size of 17.47 nm for improved bioavailability in this in vitro investigation on the treatment of breast cancer. We evaluated this curcumin nanoemulsion's anti-tumor efficaciousness on HepG2 cell lines using the MTT assay. Surprisingly, our research showed that the IC₅₀ concentrations for cells treated with curcumin nanoemulsion alone were 600 ng/ml, while the IC₅₀ concentrations for cells treated with curcumin nanoemulsion plus laser therapy were 850 ng/ml. The produced curcumin had encouraging benefits. The created curcumin nanoemulsion has a lot of potential for use as a strong anticancer medication. In summary, PDT of curcumin nanoemulsion shows a major involvement in the death of cancer cells via many apoptotic mechanisms.