Behçet's disease (BD) is a chronic inflammatory condition that recurs and is characterised by oral and vaginal ulcerations, ocular symptoms, and other systemic involvement. The study's objective was to evaluate the degree of growth arrest-specific 5 (GAS5) expression in BD as an autoimmune disease. thirty-five patients with BD (24 males and 11 females), and 30 healthy controls (22 males and 8 females) were included in the study. Sera were separated from blood samples and stored at -80 °C until the time of analysis. These sera were used in Long noncoding extraction and detection of fold change of the gene GAS5 using real time PCR. Results: When cases were compared to controls, there was a statistically significant rise in GAS5 expression (P 0.0001). With an AUC of 0.743 (95% confidence interval (CI): 0.598-0.888; sensitivity = 74.3, specificity = 100%), the ROC curve demonstrated that Lnc RNAs are useful in discriminating BD from healthy controls).