The current investigation was carried out to examine the possible potential protective effects of ethanolic extract of the pulp of annona fruit against trichloroacetic acid (TCA) induced liver cancer. The biological experiment used twenty- four albino rats. After the adaptation period, the rats were divided into four groups (6 rats each). One of them was considered as a negative control and another positive control (Trichloroacetic acid group). The remaining groups were divided into two groups consisting of extracts from pulp at levels 100 and 150 mg / kg. Feed consumption was recorded daily, and the rats' body weights were assessed once a week. After the experiment period (47 days) had passed blood samples were collected to assays the levels of (WBC, RBC, HGB, PLT, HCT, MCV and MCHC) liver functions (ALT, AST, ALP, BIL, TP, ALB and GLB), some kidney functions (creatinine and urea), and oxidation stress (CAT, GPX and MDA). Liver tissues were collected for inflammation markers analyses (IL6, AFP, COX2 and PGE2).The study results were as the fallowing: all liver cancer protected groups by extracts of annona pulp at doses of 100 and 150 mg/kg of rat weight showed a significant improvement in rats weights, complete blood count, liver functions, some kidney functions, oxidation stress and inflammation markers, when compared them with the unprotected liver cancer group (+ve).