Background: An ethical work climate represents the common perception employees have regarding the policies, practices and procedures which an organization awards, supports and expects in relation to ethics. Patient safety is the avoidance of unintended or unexpected harm to people during the provision of health care. Aim of the study was to assess the ethical work climate and its relation to patients' safety as perceived by staff nurses. Study design: Descriptive correlational design was used in the study. Setting: The study was conducted in all inpatients' units at medical and surgical departments at Benha University Hospital. Study subjects: A simple random sample of nurses including 327 nurses working in the same setting. Tools of data collection: Two tools were used; Tool I: Ethical work climate scale and Tool II: Patients' safety questionnaire. Results: About half of the studied staff nurses (47.4%) perceived that there was high level of ethical work climate and more than half of the studied staff nurses (57.8%) perceived that there was high level of patients' safety. Conclusion: There was a highly statistical significant positive correlation between total level of ethical work climate and total level of patients' safety as perceived by staff nurses. Recommendations: Conducting workshops in the organization to reinforce ethical work climate and keep the progress of patient safety.