Background: Post resuscitation educational Program developing put a guideline to the patient to be safe as possible from post arrest complication. The study aimed to evaluate the effect of post resuscitation educational program on critical care nurses' performance among patients with cardiac arrest complications. Design: A Quasi experimental design was used in carrying out this study. Settings: the study conducted at critical units at Benha University Hospital. Subjects: Nurses: Convenient sample of nurses (105) who are working in the above-mentioned setting: and a purposive sample of 60 adult patients were including in study. Tools: Tool I. Nurses' Self administration questionnaire sheet aimed to assess nurses' knowledge, Tool II. Observational checklists amid to assess nurses' practice regarding care of patient post cardiac arrest Tool (III) Patients outcomes to assess patients' outcome post cardiac arrest. Results: 45% of nurses had good knowledge before the implementation for them and 79% post-implementation. Also, nurse's practice improved from zero% pre-implementation to 91.4% post-implementation, all patient's had sever impairment preprogram implementation and 62.6of them improved to mild impairment post program Conclusion: The study revealed that the all nurses had poor total level of knowledge before the intervention which most of them their practice was improved to more than three quarters of them post implementation. Regarding nurses' practice, the results of the current study illustrated that none of nurses had satisfactory practice pre-program implementation which most of them their practice was improved post-program implementation, patient outcome improved post program. Recommendations: Researchers should continuously create educational programs for nurses regarding caring for post cardiac arrest patients, including preventive measures and management of complications.