Background: Panel discussion has been implemented throughout the world as an innovative learning method in nursing education. It enhances students' knowledge, practices, promotes self-learning, and improves their self-confidence and engagement. Aim of the study: To determine fourth year nursing students' self- confidence and engagement by using panel discussion strategy. Study design: Aquasi-experimental design was used in this study. Setting: The study was conducted at Faculty of Nursing, Benha University. Study subjects: A systematic random sample of the fourth year nursing students (n=57) who were enrolled in the first term of the academic year 2020-2021 and studied nursing administration course. Data collection tools: Tool I: Panel discussion strategy knowledge questionnaire, Tool II: Panel discussion strategy observational checklist, Tool III: Self-confidence scale and Tool IV: Student engagement questionnaire. Results: Less than three quarters (71.9% &70.2%) of the fourth year nursing students had good level of knowledge regarding panel discussion strategy at immediate post-program phase, and follow up-phase (after 3 months)  of program respectively, more than three quarters (75.4%) of the fourth year nursing students had a high level of practice regarding panel discussion strategy at immediate post-program phase, while it slightly decreased to 72% at follow up phase (after 3 months), more than three quarters (77.2%) had a high level of self-confidence at immediate post-program phase, while it slightly decreased to 73.3% in follow up phase (after 3 months) and the majority (80.7%) had a high level of student engagement at immediate post-program phase, while it slightly decreased to 77.2% in follow up program phase (after 3 months). Conclusion: Implementation of panel discussion strategy program led to significant improvement of fourth year nursing students' knowledge, practice regarding panel discussion strategy, self-confidence and engagement. Recommendations: Integrating panel discussion strategy into the nursing curriculum as a teaching method in the Faculty of Nursing side by side with lecture to get a complete picture of nursing students' self-confidence and engagement in their professional development and lifelong learning.