Background: Parkinson's disease causes severe burden on patients and society and affect all aspects of patient's life so improving quality of life of patients keep them more adaptable to  physical, psychological and  social status. Aim of the study: This study was conducted to assess quality of life for patient with Parkinson's disease. Research design: Descriptive research design was utilized. Setting: The study was conducted at Neurology Outpatient Clinics at Benha University Hospital.  Sample Type: Convenience sample of all patients with Parkinson disease, the total sample included 75 patients through 6 months. Tools: Three tools were used for data collection. (1): A structured interviewing questionnaire consisted of two parts to assess Socio-demographic characteristics and knowledge of patients regarding Parkinson's disease. (II): Scale of independency level of performing daily living activities, and (III): Scale of quality of life for patients with Parkinson's disease Results: 70% of studied patients had good level of knowledge related to Parkinson's disease. While 17% of them had an average level of knowledge. 62.7% of studied patients had a partial level of independence, while 37.3% of them had independence. 60% of studied patients had an average level of quality of life and 29.4% of them had poor level of quality of life, while 10.6% of them had good level. Conclusion: There was a highly statistically significant relation between total quality of life of studied patients and level of independency. Recommendation:  Educational program should be developed and implemented for patients with Parkinson's disease to help them to be more coping with their physical, psychological and social status.