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371879

Genetic polymorphisms of ACE2 G8790A (rs2285666) and Apo E (rs 121918398) in Alzheimer's disease among cohort of Egyptian patients: Relation to disease susceptibility and severity

Article

Last updated: 27 Dec 2024

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Subjects

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Tags

Biochemistry and Molecular Biology
Neuropsychiatric diseases.

Abstract

Background: Multiple family members have been reported to have Alzheimer's disease (AD), according to family and twin studies. Several ApoE genetic variations have been linked to AD because of their involvement in lipid dysregulation. It has been observed that the Angiotensin converting enzyme 2 (ACE2) gene influences the accumulation of β-amyloid peptide (Aβ).
Objectives: To assess the ACE2 G8790A (rs2285666) and Apo E (rs 121918398) SNPs among cohort of Egyptian AD patients and to explore their probable connection to the occurrence and severity of AD.
Patients and methods: This is a case-control research included 50 Egyptian patients with AD and 50 healthy participants. AD patients were assessed using mini-mental state examination. Genetic analysis for ACE2 (rs2285666) SNPs and Apo E (rs 121918398) SNPs was done using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR).
Results: The age, and gender distributions of the study and control groups were matched. Patients with AD were more prevalent in rural areas. In terms of ACE2 genotyping, a higher frequency of AA genotype and A allele in the AD group, indicating their significant association with increased AD risk. They were linked to the severity of the illness as well. Regarding Apo E genotyping, there were statistically frequent (P<0.001) E4 allele and the E3/E4 genotype among the AD group, and were considerably linked to more severe illness.
Conclusion: An ACE2 homozygous mutation with an A allele is thought to be a genetic risk factor and major predictor of the severity of AD. The incidence and severity of AD are significantly predicted by the APO E4 allele.

DOI

10.21608/svuijm.2024.307257.1942

Keywords

Genetic polymorphisms, Alzheimer’s disease, Angiotensin converting enzyme, apolipoprotein E, Egypt

Authors

First Name

Tarek

Last Name

Desoky

MiddleName

-

Affiliation

Psychiatry Department; Faculty of Medicine; South Valley University; Qena 83523, Egypt

Email

tarekdesoky@rocketmail.com

City

-

Orcid

-

First Name

Mohammed H.

Last Name

Hassan

MiddleName

-

Affiliation

Department of Medical Biochemistry , Faculty of Medicine, South Valley University, Qena, Egypt

Email

mohammedhosnyhassaan@med.svu.edu.eg

City

-

Orcid

0000-0003-2698-9438

First Name

Khaled Ahmed

Last Name

Elbeh

MiddleName

-

Affiliation

Psychiatric Department, Faculty of Medicine, Assuit University; Assiut 71525, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed Abdala

Last Name

Abbas

MiddleName

-

Affiliation

Neurology Department; Faculty of Medicine, Luxor University; Luxor 85951, Egypt

Email

-

City

-

Orcid

-

First Name

Samer A.

Last Name

El-Sawy

MiddleName

-

Affiliation

Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan. & Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

-

City

-

Orcid

-

First Name

Shimaa Fathy

Last Name

Sakr

MiddleName

-

Affiliation

Molecular Biology Unit, Medical Technology Center, Medical Research Institute, Alexandria 21131, Egypt.

Email

-

City

-

Orcid

-

First Name

Mahmoud Ahmed

Last Name

Bekiet

MiddleName

-

Affiliation

Psychiatry Department; Faculty of Medicine; South Valley University; Qena 83523, Egypt

Email

-

City

-

Orcid

-

First Name

Reham Bakry

Last Name

Mohamed

MiddleName

-

Affiliation

Neurology Department; Faculty of Medicine, Luxor University; Luxor 85951, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed Moslem

Last Name

Hefny

MiddleName

-

Affiliation

Psychiatry Department; Faculty of Medicine; South Valley University; Qena 83523, Egypt

Email

-

City

-

Orcid

-

Volume

7

Article Issue

2

Related Issue

47977

Issue Date

2024-07-01

Receive Date

2024-07-25

Publish Date

2024-07-01

Page Start

325

Page End

339

Print ISSN

2735-427X

Online ISSN

2636-3402

Article File

SVUIJM_Volume 7_Issue 2_Pages 325-339.pdf

PDF . 494.2kB

Link

https://svuijm.journals.ekb.eg/article_371879.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=371879

Order

371,879

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Genetic polymorphisms of ACE2 G8790A (rs2285666) and Apo E (rs 121918398) in Alzheimer's disease among cohort of Egyptian patients: Relation to disease susceptibility and severity

Details

Type

Article

Created At

27 Dec 2024