Background: Behçet's disease (BD) is an idiopathic, chronic, relapsing, multi-systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, ocular disease and skin lesions. 
Objectives: The purpose of this study was to investigate the clinical features of Behcet's Disease in Upper Egypt.
Patients and Methods: This study is a prospective observational study that conducted during the period extended from December 2017 to September 2018 in the Rheumatology Department of Sohag University Hospital. A total of 50 patient diagnosed as Behcet was included in the study.
Results: The results of this study cleared that, the higher symptoms were oral ulcer 50 (100 %), followed by genital ulcer 44 (88 %), the skin lesions appeared in 40 (80 %) and ocular lesions appeared in 34 (68 %).Meanwhile, the vascular lesions appeared in 13 (26 %) and neurological manifestations occur in 5 (10%).
Conclusion: The study concluded that, the BD is a serious disease affecting human and take many forms that includes oral, genital ulcer , skin and ocular lesions which are the predominant forms in Upper Egypt while, the vascular and neurological forms are of lower incidence.