Abstract: Renal Failure among children has the potential for not only devastating a child's health but can also place a burden on the whole family. Micro-learning is an easy learning strategy which improves knowledge about adherence to treatment, overcoming complication and decreasing morbidity. The purpose of this study was to evaluate the effect of micro-learning strategy on caregivers' knowledge and practices of children undergoing hemodialysis. A quasi –experimental design (one group pre & posttest) was utilized for this study. It was conducted at the Pediatric Hemodialysis Unit, Menoufia University Hospital – Shebin El-Kom city. Sample: A convenience sample of all caregivers who have children undergoing hemodialysis (n=36) was included. Two instruments for data collection were used; structured interviewing questionnaire. Instrument two; included caregivers' reported practice checklist. The results of this study showed that there were highly statistical significant differences between caregivers' knowledge on post and follow up test compared to pretest (95.20% & 90.20% Vs. 3.50%). Also, there were highly statistical significant differences between caregivers' reported practices on post and follow up test compared to pretest (94.00% & 93.00% Vs. 15.0 %). The study concluded that the caregivers had satisfactory knowledge and reported practices after implementation of micro-learning strategy. Therefore, this study recommended that continuous micro-learning sessions should be scheduled regularly for caregivers in the Pediatric Hemodialysis Units to increase caregivers' knowledge and improve their practice. So, quality of care and children's outcomes will improve.