Background: The performance of nurses is influenced by various dynamic factors; one of these factors is job insecurity at the workplaces. The performance is mainly affected when concerned nurses feel unsecure and thus show limited efforts towards the attainment of their work assignments and tasks. Design: A correlational research design.  Setting: The study was conducted in selected units at Menoufia University Hospital. Sample: Staff nurses who had at least one year of experience working in the hospital and accepted to participate in the study. Data collection Instruments: Two instruments were used in the study: instrument one: Job Insecurity scale and instrument two: The Individual Work Performance Questionnaire. Results: Nearly half of the studied staff nurses at Menoufia University Hospital had low level of job insecurity. Moreover, more than half of the studied staff nurses had high level of job performance. Conclusion: There was a negative relation between job insecurity and total job performance. Recommendations: Healthcare organization could deliver training programs for their managers aimed at enhancing the use of fair procedures in allocating outcomes and developing their autonomy, supportive behaviors to improve nurses' job performance and reduce nurses' job insecurity.