Abstract: Background: Mindfulness is an attention and awareness of the present moment that enables head nurses to be aware of themselves and environment surrounding them. It also assists head nurses to cope with organizational changes and stress, resulting in motivating staff nurses to generate, search and apply novel ideas in workplace. Purpose of the study: To determine head nurses' mindfulness and it's relation to their staff nurses' innovative work behavior at Menoufia University Hospital. Design: A descriptive correlational research design was used. Setting: This study included selected inpatient departments and closed units of Menoufia University Hospital at Shebin EL-Kom. Subjects: This study included all head nurses and a simple random sample of 255 staff nurses who work in selected units at Menoufia University Hospital at Shebin El-Kom and accepted to participate in the study. Tools of the study: Two instruments were utilized by the investigator. Instrument one was Five Facet Mindfulness Questionnaire, Instrument two was Innovative Behavior Inventory. Instruments were face and content validated by 5 experts Results: More than two-thirds of head nurses had moderate level (67.5%) of mindfulness. The highest mean score of mindfulness dimension as perceived by head nurses (73%) was related to describing dimension, while the lowest mean score (58.5%) was related to acting with awareness dimension. Near to half of staff nurses had a moderate level (45.9%) regarding innovative work behavior. The highest mean score (72.9%) was related to involving others dimension, while the lowest mean score (66.5%) was related to implementing starting activities dimension for staff nurses.  Conclusions: There was a highly positive statistical significant correlation between total head nurses' perceived mindfulness and total perceived innovative work behavior among staff nurses. Recommendations: Hospital administration should collaborate with staff development department to provide continuing education program to develop head nurses' mindfulness in workplace. Hospital administration should develop the perception of innovative work behavior and provide activities that develop innovation among staff nurses.