Abstract: Nurses should offer a holistic package of care to patients undergoing gastrointestinal endoscopy before, during and after endoscopy procedure to prevent any hazards or complications and improve patients' satisfaction Purpose: To examine the effect of educational nursing intervention on selected patient's outcomes among patients with upper gastrointestinal endoscopy. Design: A quasi-experimental research design was utilized. Setting: The study was carried out at the endoscopic unit of Liver Institute at Shebin EL Kom District, Menoufia Governorate. Sample: A purposive sample of one hundred of patients was selected. Instruments: Two instruments were used. Instrument one: structured interview questionnaire. Instrument two: patient evaluation sheet. Results: there was improvement in patient's knowledge related to endoscopy care post intervention (54%) than pre intervention (zero %). Complications related to patients were decreased post intervention than pre intervention. Conclusion: The study concluded that implementing nursing intervention on patients with upper gastrointestinal endoscopy had a positive effect on patients' outcomes. Recommendation: A simple booklet includes the most important instructional points regarding endoscope that should be given to all patients.