People with intellectual disabilities, especially students experienced inferior health and poor access to good quality. Students with intellectual disabilities usually prevailed oral health disparities than their normal peers as they have lower oral health index. Optimum oral health is associated with improvement in the quality of students' life. Those students need support to maintain optimal oral health outcomes for that good oral health education can have a positive impact on students with intellectual disabilities. The aim of this study is to assess knowledge level of primary caregivers and teachers of students with IDs regarding oral hygiene. Method. A cross-sectional study design was utilized to accomplish this study. A purposive sample of 54 students with Intellectual Disabilities (IDs), 54 of their primary caregivers and 54 of their teachers. Results indicated that 100 % of primary care givers and 98.1% of teachers had poor level of knowledge regarding oral hygiene. The researchers conclude that almost all primary care givers and teachers of students with IDs have poor level of knowledge regarding oral hygiene. Accordingly, the researcher recommended to design educational program to raise primary care givers and teachers of students with IDs awareness' regarding oral hygiene.