Background: Organizations are challenged with the need to implement changes in culture, structure, strategy,
and process to adapt changing market. Thus change preparedness is a critical factor in successful change. To assist
nurses to be prepared and ready for change, they require providing them with a safe, professional , empowered and
supportive environment. Aim: To assess the effect of professional nursing practice environment and structure
empowerment on nurses' readiness for change. Methods: Descriptive correlational design was utilized, and the study
was conducted on 252 nurses working at Timayy Al Imdid Central Hospital. Three tools were utilized, Practice
Environment Scale of the Nursing Work Index, Conditions for Work Effectiveness Questionnaire and Readiness for
Change Scale. Results: Over two thirds of nurses experienced moderate level of professional nursing practice
environment and structure empowerment, more than half of them had high level of readiness for change and the
professional nursing practice environment, structure empowerment, and nurses' readiness for change showed highly
statistically significant positive correlations Conclusion: The professional nursing practice environment, structure
empowerment, and nurses' readiness for change showed highly statistically significant positive correlations:.
Recommendations: Providing adequate staffing, equipment and supplies as possible to maintain safe and professional
environment, Involving nurses in decision making to feel ready for change. Showing recognition and appreciation for
nurses' work and effort, empowering them, and providing support especially in difficult situation and regular sharing in
training programs and workshops.