Background: Chemotherapy extravasation is serious problem, causing a damage that may range from a minor
skin reaction to full-thickness burn , muscle , tendon necrosis and results in extending hospital stays, increasing
morbidity, and treatment costs. Aim: Enhance oncology nurses' competency regarding management of intravenous
chemotherapy extravasation. Method: A quasi-experimental design one-group pretest posttest was used with a sample of
63 nurses working at the medical department and chemotherapy installation unit at Oncology Center at Mansoura
University Hospital. Tools: Two tools were used: Tool 1: Structured Interview questionnaire . Tool 2: Nurses' practice
observational checklist. Results: Nurses' knowledge levels improved regarding chemotherapy extravasation post
educational intervention (80.7%) compared to (7%) pre educational intervention(P value <0.001*). Nurses' practice
levels improved post educational intervention(86%) compared to (50.9%) pre educational intervention(P value
<0.001*). Conclusion: There was statistically significant improvement in nurses' competency regarding chemotherapy
extravasation post educational intervention. Recommendation: Continuous in-service training programs for oncology
nurses regarding prevention and management of intravenous chemotherapy extravasation to improve their knowledge
and practice.