Infection prevention and control are challenging in most healthcare settings, and rising rates of infectious diseases are
a major concern for patients and healthcare professionals. Therefore, the current study aimed to assess nurses' knowledge and
performance of transmission-based precautions in Mahalla Fever Hospital. Through a descriptive cross-sectional study
design; 243 nurses were involved conveniently from Mahalla Fever Hospital, Gharbia governorate. The researcher collected
socio-demographic and occupational characteristics, assess knowledge by two self-administrated structured questionnaires,
and documented performance on observational chuckle`, for nurses. Results declare that 56.8% and 95.5% of nurses had poor
knowledge and incompetent performance, levels respectively regarding transmission-based precautions. The researcher
concludes that; the highest percentages belonged to nurses with poor knowledge and incompetent performance, levels;
regarding transmission-based precautions. Finally, the study recommends conducting on-duty training programs for nurses on
transmission-based precautions. In addition to striating on monitoring and coaching nurses' performance of transmission
based precautions by the infection control team