Background: For critically ill patients undergoing gastrointestinal surgery, blood transfusions are frequently necessary
to correct anemia or replace significant blood loss from related trauma or surgical operations. Ensuring the safety of
blood transfusion procedures is the role of critical care nurses in the intensive care unit (ICU). Aim: The current study
aimed to investigate critical care nurses' compliance with blood transfusion guidelines in Gastrointestinal ICUs.
Method: A descriptive observational research design was used to conduct this study with a convenience sample of 49
critical care nurses working in three ICUs affiliated with a university hospital in Egypt. Critical care nurses' compliance
with the blood transfusion practice tool was used to collect data for this investigation. Results: Most of the participant
nurses (81.6%) had satisfactory practice levels regarding their compliance with blood transfusion guidelines with a total
mean practice score of 86.5±2.1. All participant nurses showed a satisfactory level of practice regarding patient
identification, and collection, delivery, and administration of blood components. However, 91.8% of the participant
nurses had unsatisfactory practice levels regarding checking blood requests and documentation. Conclusion and
Recommendations: The study highlights the need for periodic refresher training sessions for critical care nurses on
updated blood transfusion guidelines with a specific focus on checking blood requests and documentation of blood
transfusion. This will enhance nurses' practice, optimize patient safety and reduce blood transfusion-related
complications in ICUs.