Disinfection and sterilization are the basic components of hospital infection control activities. Every day several invasive
procedures are being performed in different health facilities. Improper sterilization or disinfection of devices is
associated with increasing risk of nosocomial infection. Nurses play a critical role in reprocessing respiratory equipment
by adhering to infection prevention and control measures. This study aimed to assess nurses' knowledge, performance,
and attitude regarding respiratory instrument processing in Mansoura hospitals. Method: A cross section study design
was used. Setting: The study was conducted at four governmental hospitals in Mansoura city. (Chest hospital, Mansoura
university hospital, Talkha, and Mansoura general hospital). Sample size: the study was carried out on 50 nurses who
are responsible for instrument processing. The researcher used four tools in this study. Tool I: Nurses' socio demographic
and occupational characteristics self-administrated questionnaire. Tool II: self-administrated questionnaire to assess the
nurses' knowledge about instrument processing process (cleaning, disinfection, inspection, packing, sterilization,
transport, storage, use and infection control measure), Tool III: Rubric observational checklist of respiratory instrument
processing performance, Tool IV: Self-administered scale to assess attitude of nursing staff about the management of
respiratory instrument processing. Results: the current study indicates that 60%, 66 % of studied nurses have poor total
score level of knowledge and improper performance respectively regarding respiratory instrument processing.
Conclusion: The study concluded that, most of the studied nurses have poor total knowledge score level, improper
performance regarding respiratory instrument processing and the mean of total positive attitude was 44.8 (5.1).
Recommendation: design protocol for nursing staff about respiratory instrument processing in Mansoura hospitals.