Sometimes nurses may be in a hurry to save a patient's life in an emergency condition. Application of normal procedures for
standard precaution may not be performed. Therefore, they should have competencies in knowledge, attitudes and practices
about infection prevention and control in health care setups. So this study aimed to assess nursing staff's knowledge, practice
and attitude about infection prevention and control measures in emergencies. A cross sectional study design was carried out in
all departments belonged to Mansoura Health Insurance Hospital affiliated to Ministry of Health, and Population, on a
convenient sample technique included all on job nursing staff (400), using four tools to assess nursing staff's socio
demographic and occupational characteristics, as well their knowledge, attitude and practice about infection prevention and
control measures in emergencies. Results: illustrates that 94.5% and 100% of nursing staff had poor score level of knowledge
and improper practice regarding infection prevention and control measures in emergencies respectively with total attitude
score of 39.55 (5.54). It is concluded that; most of nursing staff have poor score level of knowledge and all of them have
improper practice relating infection prevention and control measures in emergencies. Nursing staff illustrate negative attitude
more than positive one towards infection prevention and control measures in emergencies. Finally; on job training programs
to nursing staff on infection prevention and control in emergencies, equip and supply health care settings with all requirements
to apply and adhere to infection prevention and control in emergencies and emphasize on hand hygiene as a milestone in
infection prevention and control in emergencies, were recommended.