Background: Oder adults are more prone to polypharmacy that much more complex than just the number of
medications. Poor medication knowledge can have a negative impact on medication adherence and patient safety. Older
adult's attitudes about medications are a major determinant of patients' behaviors. Aim: Assess older adults' knowledge
and attitudes towards polypharmacy. Design: Descriptive cross sectional design was used .Setting: This study was
conducted at health insurance and health maintenance expense pharmacies in Bany Ebied Specialty hospital and Dikrnes
General hospital in Dakahlia Governorate. Subjects: A purposive sample of 352 geriatric patients with polypharmacy
was enrolled in the study. Tools: Data was collected using 3 tools; Demographic data and Medications information,
Medication Knowledge evaluation questionnaire and Patients' Attitudes towards Deprescribing questionnaire. Results:
Age of the studied older adults' patients ranged from 60 to 89 years, with a mean age of 68.35±6.017 year, males were
more prevalent. Among the studied older adults 63.1%have insufficient knowledge about their medication. Majority of
older adult patients(65.9%) agree with feeling having a large amount of medication, 69.6% not agree with feeling
comfort with the number of their medications and 67.0% of older adults would to stop one or more of their medication
to pay fewer. In addition, a strong negative correlation was found between older adult age and mean of knowledge
(P=.000**)and positive correlation was found between educational level and mean of knowledge(P= .000**), there is no
statistical significant relation was found between willing to deprescribe and older adult age (P= .348). Conclusion:
Older adults knowledge about their medications was low and majority of them would to stop one or more of their
medication. Recommendation: Designing an educational program for improving understanding of the pharmacotherapy
should be implemented with the use of designs, colors and symbols to improve older adults' knowledge and attitudes
about pharmacotherapy.